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Research and Development

Manufacturing process at Kyoto research Center
Oxygen Carrier
Enzyme-based Liposomal Drug
Research Centers and Laboratories
Business Profile

"Oxygen Carrier; development code OXY-0301", is our leading product candidate is liposome (phospholipid-based bilayer membrane) encapsulated the hemoglobin. OXY-0301 - Oxygen Carrier

Characteristic of Oxygen Carrier "OXY-0301"
OXY-0301 is designed to transport oxygen like the way human natural Red Blood Cell dose.
It is called "cell-type oxygen carrying agent " because it is designed to have high biocompatibility. This highly concentrated hemoglobin, OXY-0301 has the following features compared to conventional RBC product.

Image of OXY-0301
1. Long term storage capability
OXY-0301 can be stored for about two years in room temperature. This is rather superior to natural blood products, which has about three weeks storing capability in refrigerator.
2. Low virus risk
Our two steps to reduce virus risk, inactivation using heat-treatment and removal by nano filtration, makes the risk extremely low.
3. Universal compatibility
On the process of purification, antigens which determine blood types have been eliminated, therefore OXY-0301 can be administered to anyone.
4. High biocompatibility
OXY-0301 resembles natural human erythrocyte in behavior in blood and the same metabolic pathway will work on it.
5. Optimized molecular size
Potentional side effects, caused by passing through fenestration in blood vessel and binding to vasoconstrictors such as NO and CO out of the vessel, have been reduced by its size optimization.

Optimized molecular size

OXY-0301


Expected application  of "OXY-0301"
We have estimated some possible indications and directions and this will lead to create new market based an its widely applicable characteristics.


It is also expected that OXY-0301 can be useful in areas where healthcare services are limited. Good healthcare services, including blood transfusion, are available only in a small number of countries at present.. Some countries in Africa, Southeast Asia, Latin America, inland of the Eurasian Continent (West Asia) and China and small isolated islands have difficulties in establishing and maintaining system for natural blood products. The incidence of infections associated with blood transfusion is also very high. OXY-0301 is expected to contribute to the society in these countries and regions.



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