Liposome Formulation Technology   - Advantages in Formulation

The earliest proto-types of Oxygen Carrier, developed at School of Science and Engineering, Waseda University, were not metabolized after being taken up by the liver. This problem was solved using Bioimaging and Modeling technology developed by Professor Makoto Suematsu of School of Medicine, Keio University. Bioimaging technology Bioimaging, developed by Professor Suematsu, consists of in vivo imaging of microcirculation in organs such as the liver and brain. This technology makes it possible to observe the flow of blood components in the microcirculation and the accumulation and distribution of administered liposome in real-time. Various in vivo imaging techniques have been developed, and a number of apparatuses are commercially available. However, Oxygenix's technology has the following advantages: (1) Greater resolution (several µm to several tens µm level) (2) Visualization of multiple components as multi-color images (3) Motion imagies (4) Real-time observation in blood vessels and organs (5) Possibility of creating an artificial injury at a specific site (6) Layering of images to construct 3D images (7) Possibility of determining and analyzing the degree of accumulation of drugs in blood vessels and major organs This technology has made it possible to elucidate the mechanism of action in vivo and determining their pharmacokinetic profiles of several compounds. It has also played a major role in the development of OXY-0301. Bioimaging is used to evaluate the pharmacokinetics of drugs administered to animals by adjusting the formulation based on the data obtained. Drugs can be optimized by repeating this cycle. Joint research programs are also underway to use this breakthrough technology in libraries of pharmaceutical companies.